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L-NMMA: Pan-Specific NOS Inhibitor

Introducing L-NMMA, a highly effective pan-specific NOS inhibitor with the CAS number 53308-83-1. This powerful compound is designed to inhibit neuronal, endothelial cell, and macrophage nitric oxide synthases (nNOS, eNOS, and iNOS, respectively). With its precise action, L-NMMA offers a unique solution for researchers in various scientific fields, including neuroscience and cardiovascular studies.

• High Purity: L-NMMA is available in a powder form with a purity of greater than 98%, ensuring reliable and consistent results.
• Stable Formula: This compound has a molecular formula of C₇H₁₆N₄O₃ • CH₂COOH and a formula weight of 248.30, making it easy to handle and dissolve in aqueous solutions.

Key Features and Specifications

L-NMMA stands out for its ability to act as a mechanism-based irreversible inhibitor of iNOS, with a Ki value of 2.6 µM. It also functions as a reversible inhibitor of nNOS and eNOS, with Ki values of 0.65 and 0.7 µM, respectively. This versatility makes it an ideal tool for studying the role of nitric oxide synthases in various biological processes.

• Water Solubility: L-NMMA is highly soluble in water, up to 10 mg/ml, allowing for easy dilution in aqueous buffers.
• Storage Conditions: For optimal stability, store L-NMMA at -20°C. It maintains its integrity for at least one year, ensuring long-term use without degradation.

Applications and Usage

L-NMMA is a versatile research tool with a wide range of applications. Its pan-specific nature makes it particularly useful for studying the effects of nitric oxide synthases in both in vitro and in vivo models. Whether you're investigating the role of nNOS, eNOS, or iNOS in various diseases or exploring the underlying mechanisms of nitric oxide signaling, L-NMMA is a reliable choice.

• Neuroscience Research: Inhibiting nNOS and eNOS can help elucidate the role of nitric oxide in neuronal signaling and neurodegenerative disorders.
• Cardiovascular Studies: L-NMMA can be used to investigate the impact of iNOS on endothelial function and cardiovascular diseases.

L-NMMA is your go-to pan-specific NOS inhibitor for advanced research and discovery. Trust in its high purity, stability, and versatility to advance your scientific endeavors.