In Stock Igp-1, Mitochondrial Glyceraldehyde-3-phosphate Dehydrogenase Inhibitor (tbi3881) Gadget [Ijh693SH]

iGP-1: Mitochondrial Glyceraldehyde-3-Phosphate Dehydrogenase Inhibitor

iGP-1, also known as TBI3881, is a highly potent and cell permeable inhibitor of the mitochondrial glyceraldehyde-3-phosphate dehydrogenase (mGPDH). This novel inhibitor boasts an IC50 value of 6.3 μM, demonstrating its selectivity over the cytosolic enzyme. What sets iGP-1 apart is its ability to not block pyruvate uptake into cells or mitochondria, ensuring that glycolysis in synaptosomes remains unaffected. This unique characteristic makes iGP-1 an invaluable tool for investigating the role of glycerol-3-phosphate metabolism in both isolated and intact systems.

• High Potency: IC50=6.3 μM against mGPDH
• Selectivity: Over the cytosolic enzyme with minimal impact on glycolysis

Product Specifications

iGP-1 is available as a pure powder, ensuring its stability and purity. The product has a molecular formula of C₁₇H₁₅N₃O₃ and a formula weight of 309.30. It is highly soluble in DMSO, with a solubility of up to 50 mg/ml, making it convenient for various applications. With a purity of >98%, iGP-1 is suitable for research and development purposes.

• High Purity: >98% purity
• Solubility: Soluble in DMSO up to 50 mg/ml
• Storage: Stable at -20°C

Applications and Benefits

iGP-1's unique properties make it an essential tool for researchers studying glycerol-3-phosphate metabolism. Its potent inhibition of mGPDH, coupled with its selectivity and minimal impact on glycolysis, allows for a more accurate understanding of the role of glycerol-3-phosphate metabolism in various biological systems. This inhibitor is particularly beneficial for investigating metabolic pathways in both in vitro and in vivo settings. Ideal for researchers in the fields of biochemistry, pharmacology, and cellular biology, iGP-1 is a valuable asset in any laboratory.

• Research Tool: Investigates glycerol-3-phosphate metabolism
• Applications: Suitable for in vitro and in vivo studies
• Field: Beneficial for biochemistry, pharmacology, and cellular biology researchers