Your New Favorite Isrib, Integrated Stress Response Inhibitor (tbi1539) Tool [AsdwcmRZ]

ISRIB: The Ultimate Integrated Stress Response Inhibitor

Introducing ISRIB, a cutting-edge Integrated Stress Response Inhibitor designed to revolutionize research in neuroscience and pharmacology. This potent compound boasts an impressive purity of >98%, ensuring reliable and consistent results. With its unique molecular formula, C₂₂H₂₄Cl₂N₂O₄, and a formula weight of 451.34, ISRIB is a powerful tool for scientists seeking to understand and modulate the stress response in various biological systems.

• Enhanced spatial and fear-associated learning in mice
• Enhances cognitive function

Key Features and Specifications of ISRIB

ISRIB is a trans-ISRIB, also known as N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide], with a CAS number of 1597403-47-8. It is supplied as a powder, making it convenient for various applications. This compound is highly soluble in DMSO, up to 5 mg/ml, and can be stored at -20°C for stability and long-term use.

• IC50 of 5 nM against eIF2α phosphorylation
• Suppression of ER stress-induced inflammatory gene expression

Applications and Benefits of ISRIB

ISRIB is a versatile tool with numerous applications in the study of stress response and cognitive function. It effectively reverses the effects of initiation factor 2α (eIF2α) phosphorylation, making it a valuable tool for understanding cellular stress responses. Additionally, ISRIB potently attenuates amyloid β-induced neuronal cell death, which makes it a promising candidate for treating neurodegenerative diseases.

• Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury
• No effect on amyloid β production

With ISRIB, researchers can delve deeper into the complex mechanisms of stress and cognitive function, opening new avenues for therapeutic development.