Portable As-8351, Kdm5b Histone Demethylase Inhibitor (tbi1597) Up To 40% Off [U29AGL1t]

Description

Product Details

Formal Name: 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

Alternate Names: NSC-51355

Molecular Formula: C₁₇H₁₃N₃O₂

Formula Weight: 291.30

CAS Number: 796-42-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

KDM5B histone demethylase inhibitor

Functions

AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.

Application Procedures

First dissolved in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.