![Free Shipping 17-aag, > 98% Summer Must-have [dquOwKhR]](https://cdn.shopify.com/s/files/1/0568/5883/7069/products/BC001-1_422d116d-0f81-45a2-9500-f98f3f2f8225.jpg?v=1706491137)
![Free Shipping 17-aag, > 98% Summer Must-have [dquOwKhR]](https://cdn.shopify.com/s/files/1/0568/5883/7069/products/BC001-1_cefcec13-26df-4107-be8c-9bda843f237f.jpg?v=1706491137)
Free Shipping 17-aag, > 98% Summer Must-have [dquOwKhR]
$31.99
$102.99
-69%
17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. 17-AAG caus
Secure Shopping
100% Safe Guarantee
Free Shipping
On orders over $30
Money-Back
30-Day Guarantee
Free Shipping 17-aag, > 98% Summer Must-have [dquOwKhR]
17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants.
Store at -20℃
| IC50 | 5 nM |
|---|---|
| Target | HSP90 |
| Solubility | DMSO : 100 mg/mL (170.73 mM) Ethanol : 5 mg/mL (8.53 mM) Water : Insoluble |
| Alternative Names | NSC 330507, 17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin |
What Our Customers Say
Absolutely no complaints!
The positive reviews are all true.
- Denise Cooper.
Absolutely no complaints!
Delighted with the overall quality and performance.
- Karen Martinez.
Absolutely no complaints!
A truly great item that I'm proud to own.
- Luke Gray.
Write a Review
Thank you for your review! Your review is under moderation and will be published soon.
![Sea Catch TR7LM w/Safety Pin - Large Mouth [TR07LM]](https://cdn.shopify.com/s/files/1/0513/2618/9750/products/79215XL.jpg?v=1607309319)
