Viral Msi (Μικροδορυφορική αστάθεια) Perfect Gift [V8Ru2TPJ]

Microsatellite Instability (MSI) Detection

The MSI Detection Kit is designed to identify and determine the levels of microsatellite instability, a key characteristic that defines different subsets of tumors across various types of cancers. This instability is caused either by mutations or through epigenetic inactivation (hypermethylation of the MLH1 gene promoter) of mismatch repair genes required for correcting "mismatches" in DNA. Detecting MSI is crucial, especially in colorectal cancer (CRC), where it is present in approximately 15% of stage II and III cases.

Advanced Detection Methodology

The MSI v1.2® Promega kit is utilized for this advanced detection process. It involves analyzing specific polymorphic regions, including ΒΑΤ25, ΒΑΤ26, NR21, NR24, and MONO27, which are nearly monomorphic and thus ideal indicators for MSI. Additionally, the kit checks the polymorphic regions PentaD and PentaC to ensure the origin of the two samples from the same case. This comprehensive analysis is conducted using the ABI3130xl genetic analyzer by ThermoScientific, ensuring accurate and reliable results.

Benefits and Applications

Key Features:

• Accurate detection of microsatellite instability
• Analysis of specific polymorphic regions for precise results
• Use of the MSI v1.2® Promega kit for reliable performance
• Analysis on the ABI3130xl genetic analyzer for high-quality data

The MSI Detection Kit offers numerous benefits for healthcare professionals and researchers. It aids in early diagnosis and prognosis of cancer patients, helping to tailor personalized treatment plans. Additionally, the kit's versatility allows for its use in various research settings, contributing to a deeper understanding of cancer biology and treatment strategies.