Instant Savings Gw5074 Deal Alert: 40% Off [Ge3ArCWq]

Instant Savings Gw5074 Deal Alert: 40% Off [Ge3ArCWq] reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). It is also a potent and selective c-Raf inhibitor with IC50 of 9 nM.

References

Li, Z., Wang, C., Wang, Z., Zhu, C., Li, J., Sha, T., Ma, L., Gao, C., Yang, Y., Sun, Y., Wang, J., Sun, X., Lu, C., Difiglia, M., Mei, Y., Ding, C., Luo, S., Dang, Y., Ding, Y., … Lu, B. (2019). Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds. Nature, 575(7781), 203–209. https://doi.org/10.1038/s41586-019-1722-1

Documents 

Datasheet         COA           MSDS

Citations

If you know of a paper that uses this product from Tenova Pharma, please let us know.