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Alexa Fluor® 647 Anti-Mouse Notch 3 Antibody

The Alexa Fluor® 647 Anti-Mouse Notch 3 Antibody is a highly specialized monoclonal antibody designed for researchers studying the crucial Notch 3 pathway in mammalian cells. This antibody, clone HMN3-133, offers exceptional specificity and affinity for mouse Notch 3, making it an invaluable tool for both basic research and clinical applications. With its Alexa Fluor 647 conjugation, this antibody provides robust fluorescence, enabling clear and sensitive detection in flow cytometry and imaging experiments.

Product Specifications

This antibody is produced through a process involving Armenian Hamster cells and is formatted in a convenient Alexa Fluor 647 conjugate. The monovalent IgG antibody is optimized for use in flow cytometry, ensuring high-quality results. Its reactivity is specific to mouse Notch 3, allowing for precise targeting and analysis. The product is also regulated as RUO (Research Use Only), ensuring compliance with various research standards and protocols. Key features of this antibody include:

• High specificity: Specifically targets mouse Notch 3 with minimal cross-reactivity.
• Robust fluorescence: Alexa Fluor 647 conjugation provides bright and clear signals for easy detection.

Applications and Benefits

The Alexa Fluor® 647 Anti-Mouse Notch 3 Antibody is a versatile tool for a wide range of applications, including flow cytometry and immunofluorescence. Its ability to detect Notch 3 expression in adult arterial smooth muscle cells makes it particularly useful for studying CADASIL, an inherited early stroke syndrome linked to Notch 3 gene mutations. By using this antibody, researchers can:

• Understand Notch 3 signaling: Investigate the complex signaling processes triggered by Notch 3 translocation.
• Identify disease mechanisms: Gain insights into the role of Notch 3 in CADASIL and other related conditions.